相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Click Chemistry in Proteomic Investigations
Christopher G. Parker et al.
CELL (2020)
Acetylene Group, Friend or Foe in Medicinal Chemistry
Tanaji T. Talele
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Xiaobo Wan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond
Bo Zhao et al.
PHARMACOLOGICAL REVIEWS (2020)
The Two Deubiquitinating Enzymes from Chlamydia trachomatis Have Distinct Ubiquitin Recognition Properties
John M. Hausman et al.
BIOCHEMISTRY (2020)
Activity-based protein profiling: Recent advances in medicinal chemistry
Hui Deng et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery
Neil C. Taylor et al.
FRONTIERS IN CHEMISTRY (2020)
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors
Kirsten McAulay et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Identification and characterization of diverse OTU deubiquitinases in bacteria
Alexander F. Schubert et al.
EMBO JOURNAL (2020)
An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella
Thomas Hermanns et al.
LIFE SCIENCE ALLIANCE (2020)
Development and application of ubiquitin-based chemical probes
Xin Sui et al.
CHEMICAL SCIENCE (2020)
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Wioletta Rut et al.
CHEMICAL SCIENCE (2020)
The role of ubiquitination in tumorigenesis and targeted drug discovery
Lu Deng et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK)
Scott H. Watterson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
Elma Mons et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Breaking the chains: deubiquitylating enzyme specificity begets function
Michael J. Clague et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Emerging drug development technologies targeting ubiquitination for cancer therapeutics
Gianluca Veggiani et al.
PHARMACOLOGY & THERAPEUTICS (2019)
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
Efrat Resnick et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs)
Yuqing Jia et al.
ACS CHEMICAL BIOLOGY (2019)
Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics
Adan Pinto-Fernandez et al.
FRONTIERS IN CHEMISTRY (2019)
Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology
Matthias Gehringer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP
Henrik Johansson et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity
Robbert Q. Kim et al.
NATURE COMMUNICATIONS (2019)
Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme
Yi-Jia Li et al.
CELL CHEMICAL BIOLOGY (2019)
From Discovery to Bedside: Targeting the Ubiquitin System
Ingrid E. Wertz et al.
CELL CHEMICAL BIOLOGY (2019)
The Taxonomy of Covalent Inhibitors
Alfred Tuley et al.
BIOCHEMISTRY (2018)
Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes
David S. Hewings et al.
NATURE COMMUNICATIONS (2018)
An Internally Controlled Quantitative Target Occupancy Assay for Covalent Inhibitors
Rasmus Hansen et al.
SCIENTIFIC REPORTS (2018)
How Chemical Synthesis of Ubiquitin Conjugates Helps To Understand Ubiquitin Signal Transduction
Dharjath S. Hameed et al.
BIOCONJUGATE CHEMISTRY (2017)
Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights
David S. Hewings et al.
FEBS JOURNAL (2017)
Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile
Tjeerd Barf et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)
Ubiquitin enzymes in the regulation of immune responses
Petra Ebner et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2017)
Universal and Quantitative Method To Evaluate Inhibitor Potency for Cysteinome Proteins Using a Nonspecific Activity-Based Protein Profiling Probe
Tomoya Sameshima et al.
BIOCHEMISTRY (2017)
Drugging the undruggables: exploring the ubiquitin system for drug development
Xiaodong Huang et al.
CELL RESEARCH (2016)
Mass Spectrometric and Functional Aspects of Drug-Protein Conjugation
Arun Tailor et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2016)
MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes
Syed Arif Abdul Rehman et al.
MOLECULAR CELL (2016)
Chemical proteomics approaches for identifying the cellular targets of natural products
M. H. Wright et al.
NATURAL PRODUCT REPORTS (2016)
A computational study on the reaction mechanism and energetics of Markovnikov and anti-Markovnikov addition in alkyne hydrothiolation reactions
Elambalassery G. Jayasree et al.
COMPUTATIONAL AND THEORETICAL CHEMISTRY (2016)
Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact/KI) by Means of an Endpoint Competition Assay
Ikuo Miyahisa et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism
Stefan G. Kathman et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Practical Methods for the Synthesis of Trifluoromethylated Alkynes: Oxidative Trifluoromethylation of Copper Acetylides and Alkynes
Cedric Tresse et al.
ADVANCED SYNTHESIS & CATALYSIS (2014)
Ubiquitination in disease pathogenesis and treatment
Doris Popovic et al.
NATURE MEDICINE (2014)
Propargyl Amides as Irreversible Inhibitors of Cysteine Proteases-A Lesson on the Biological Reactivity of Alkynes
Christoph Arkona et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition
Stefanie Sommer et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases
Reggy Ekkebus et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Ubiquitin-Based Probes Prepared by Total Synthesis To Profile the Activity of Deubiquitinating Enzymes
Annemieke de Jong et al.
CHEMBIOCHEM (2012)
Differentiating Serine and Cysteine Protease Mechanisms by New Covalent QSAR Descriptors
Michael Shokhen et al.
CHEMBIOCHEM (2011)
Activity-based probes: discovering new biology and new drug targets
William P. Heal et al.
CHEMICAL SOCIETY REVIEWS (2011)
Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes
Mikael Altun et al.
CHEMISTRY & BIOLOGY (2011)
The resurgence of covalent drugs
Juswinder Singh et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance
Sabine Klueter et al.
CHEMBIOCHEM (2010)
Reaction Rates and Mechanisms for Radical, Photoinitated Addition of Thiols to Alkynes, and Implications for Thiol-Yne Photopolymerizations and Click Reactions
Benjamin D. Fairbanks et al.
MACROMOLECULES (2010)
Ubiquitin C-Terminal Electrophiles Are Activity-Based Probes for Identification and Mechanistic Study of Ubiquitin Conjugating Machinery
Kerry Routenberg Love et al.
ACS CHEMICAL BIOLOGY (2009)
Determination of active enzyme concentration using activity-based probes and direct mass spectrometric readout
Cedric Bovet et al.
ANALYTICAL BIOCHEMISTRY (2008)
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
Marcin Drag et al.
BIOCHEMICAL JOURNAL (2008)
Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids
Michal Hocek et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2008)
6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases
Edgar R. Wood et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme
A Borodovsky et al.
CHEMISTRY & BIOLOGY (2002)
Kinetic and titration methods for determination of active site contents of enzyme and catalytic antibody preparations
K Brocklehurst et al.
METHODS (2001)
分享论文
