期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 143, 期 11, 页码 4148-4153出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.1c00593
关键词
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资金
- Research Grants Council of HKSAR [14305017, 14305918]
- NSFC/RGC Joint Research Scheme [N_CUHK402/18]
- CUHK Impact Postdoctoral Fellowship Scheme (IPDFS)
- Innovation and Technology Commission (HKSAR)
This study presents a new method for the selective amination of o-carboranes with NH3 gas via Ir catalysis, providing a convenient and efficient access to a series of 3-NH2-o-carborane derivatives. The use of NH3 gas as the amination reagent with H2 as the sole byproduct makes the protocol economical, practical, and environmentally friendly.
Ammonia gas, NH3, is a cheap and widely used industrial feedstock, which has received tremendous research interests in its functionalization. This work reports a breakthrough in catalytic selective cage B(3)-H amination of o-carboranes with NH3 via Ir-catalyzed B-H/N-H dehydrocoupling, offering convenient and efficient access to a series of 3-NH2-o-carborane derivatives in moderate to high isolated yields with a broad substrate scope. The employment of readily available NH3 gas as the aminating reagent with H-2 as the sole byproduct endows the protocol economy, practicability, and environmental friendliness. A plausible reaction mechanism is proposed on the basis of control experiments.
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