4.8 Article

Enhanced Suppression of a Protein-Protein Interaction in Cells Using Small-Molecule Covalent Inhibitors Based on an N-Acyl-N-alkyl Sulfonamide Warhead

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent

Vikram Thimaradka et al.

Summary: In this study, a new reactive peptide tag/probe pair system for site-specific covalent protein labeling was developed. The method relies on the recognition-driven reaction of a peptide tag and a molecular probe. The reactive profile and site-specificity of this method were characterized using model peptides and proteins in vitro, and the general utility for production of a nanobody-chemical probe conjugate without compromising its binding ability was demonstrated.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Development of a Cell-Based Ligand-Screening System for Identifying Hsp90 Inhibitors

Tsuyoshi Ueda et al.

BIOCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Global targeting of functional tyrosines using sulfur-triazole exchange chemistry

Heung Sik Hahm et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Chemistry, Multidisciplinary

Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90

Adolfo Cuesta et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Multidisciplinary

Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins

Keisuke Tokunaga et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Medicinal

Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues

Luca Gambini et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Chemistry, Multidisciplinary

Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems

Tomonori Tamura et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Biochemistry & Molecular Biology

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Naoya Shindo et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Chemistry, Multidisciplinary

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides

Jiraborrirak Charoenpattarapreeda et al.

CHEMICAL COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation

Tinghu Zhang et al.

CELL CHEMICAL BIOLOGY (2019)

Article Chemistry, Multidisciplinary

Inverse Drug Discovery Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

David E. Mortenson et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Review Chemistry, Multidisciplinary

Structure-based design of targeted covalent inhibitors

Richard Lonsdale et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Biochemistry & Molecular Biology

jPOSTrepo: an international standard data repository for proteomes

Shujiro Okuda et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biochemistry & Molecular Biology

Targeting the N terminus for site-selective protein modification

Christian B. Rosen et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Chemistry, Multidisciplinary

Targeted Covalent Inhibitors for Drug Design

Thomas A. Baillie

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Chemistry, Multidisciplinary

Proximity-enabled bioreactivity to generate covalent peptide inhibitors of p53-Mdm4

Christian Hoppmann et al.

CHEMICAL COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M

Kenneth S. Thress et al.

NATURE MEDICINE (2015)

Article Chemistry, Multidisciplinary

Synthesis of gamma-labeled nucleoside 5 '-triphosphates using click chemistry

S. Serdjukow et al.

CHEMICAL COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

Michelle R. Arkin et al.

CHEMISTRY & BIOLOGY (2014)

Article Biochemistry & Molecular Biology

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Bryan R. Lannine et al.

NATURE CHEMICAL BIOLOGY (2014)

Review Biotechnology & Applied Microbiology

Drugging the p53 pathway: understanding the route to clinical efficacy

Khoo Kian Hoe et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Chemistry, Medicinal

Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development

Qingjie Ding et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Chemistry, Multidisciplinary

Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors

Klaus Michelsen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Biochemistry & Molecular Biology

Protein-protein docking benchmark version 4.0

Howook Hwang et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)

Article Chemistry, Multidisciplinary

Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction

Jeffrey P. Plante et al.

CHEMICAL COMMUNICATIONS (2009)

Article Multidisciplinary Sciences

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

Marzena Pazgiera et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

LT Vassilev et al.

SCIENCE (2004)

Review Biochemistry & Molecular Biology

Covalent modification as a strategy to block protein-protein interactions with small-molecule drugs

JC Way

CURRENT OPINION IN CHEMICAL BIOLOGY (2000)