期刊
JOURNAL OF SEPARATION SCIENCE
卷 44, 期 12, 页码 2399-2407出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.202001244
关键词
dispersive solid‐ phase extraction; high‐ performance liquid chromatography; hydrophilic polymers; magnetic molecularly imprinted polymers; sulfonamides
资金
- Department of Science & Technology of Shandong Province, China [2018GNC110029]
- Beijing Laboratory of Food Quality and Safety, Beijing Technology and Business University [FQS-201805]
- Open Project Program of State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science Technology [SKLFNS-KF201805]
Highly hydrophilic magnetic molecularly imprinted polymers were prepared for the detection of trace levels of sulfonamides in animal-derived samples, showing excellent specific adsorption properties for the target template compound. The method, with good linear performance and high recoveries in spiked samples, avoids the use of organic solvents and simplifies the pretreatment process. This approach holds great potential for rapid detection of drug residues.
Highly hydrophilic magnetic molecularly imprinted polymers were prepared through a surface imprinting technique for dispersive solid-phase extraction coupled with high-performance liquid chromatography to detect trace levels of ten sulfonamides in animal-derived samples. The obtained imprinted polymers were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and adsorption experiments, which exhibited excellent specific adsorption for template sulfamethazine in aqueous solution. Moreover, the adsorption process could be completed within 25 min. Under the optimum conditions, the method exhibits good linear performance in the range of 5-to 10 mg/L, limits of detection ranging from 0.57 to 1.50 mu g/L, and good recoveries of 85.09-110.93% in the spiked samples (chicken, cow milk, and goat milk). The proposed detection method not only avoids the use of organic solvents but also simplifies the pretreatment procedure via excellent magnetic properties. Furthermore, the method shows great potential for the rapid detection of drug residues.
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