期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 46, 期 5, 页码 1168-1179出版社
WILEY
DOI: 10.1002/eji.201546179
关键词
Aging; Human; NK cells; T lymphocytes; Viral infection
类别
资金
- Agence de biomedecine [R14107DD]
- Vaincre la Mucoviscidose (VLM)
- Association Gregory Lemarchal [RF20140501153]
- Fondation pour la Recherche Medicale (FRM) [DEQ20120323690]
NK cells are key players in the fight against persistent viruses. Human cytomegalovirus (HCMV) infection is associated with the presence of a population of CD16(+) CD56(dim) NKG2C(+) NK cells in both acutely and latently infected individuals. Here, we studied the nature of these terminally differentiated NK cells in different human populations infected with HCMV: healthy donors stratified by age, thymectomized individuals, pregnant women suffering from primary CMV infection, and lung transplant patients. Both CD16(+) CD56(dim) NK- and CD8 T-cell phenotypes as well as functional capacities were determined and stratified according to age and/or CMV event. Similarly to T-cell responsiveness, we observe an accumulation over time of NKG2C(+) NK cells, which preferentially expressed CD57. This accumulation is particularly prominent in elderly and amplified further by CMV infection. Latent HCMV infection (without replication) is sufficient for NKG2C(+) CD57(+) NK cells to persist in healthy individuals but is not necessarily required in old age. Collectively, the present work supports the emerging concept that CMV shapes both innate and adaptive immunity in humans.
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