期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 46, 期 7, 页码 1574-1582出版社
WILEY
DOI: 10.1002/eji.201546176
关键词
Cancer; Chronic infection; Metabolism; Negative regulatory receptors; T cells
类别
资金
- TELEVIE [7.4512.13, 7.4535.12]
- Interuniversity Attraction Poles (BELSPO) [P7/39]
T-cell metabolism is central to the shaping of a successful immune response. However, there are pathological situations where T cells are rendered dysfunctional and incapable of eliminating infected or transformed cells. Here, we review the current knowledge on T-cell metabolism and how persistent antigenic stimulation, in the form of cancer and chronic viral infection, modifies both metabolic and functional pathways in T cells.
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