期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 46, 期 6, 页码 1315-1325出版社
WILEY
DOI: 10.1002/eji.201545562
关键词
Adipose tissue; Diabetes; Group 2 innate lymphoid cells; Metabolism; Type 2 immunity
类别
资金
- NIH [K08DK101604]
- UCSF REAC Grant
- UCSF Department of Laboratory Medicine
Adipose tissue (AT) is home to an abundance of immune cells. With chronic obesity, inflammatory immune cells accumulate and promote insulin resistance and the progression to type 2 diabetes mellitus. In contrast, recent studies have highlighted the regulation and function of immune cells in lean, healthy AT, including those associated with type 2 or allergic immunity. Although traditionally activated by infection with multicellular helminthes, AT type 2 immunity is active independently of infection, and promotes tissue homeostasis, AT browning, and systemic insulin sensitivity, protecting against obesity-induced metabolic dysfunction and type 2 diabetes mellitus. In particular, group 2 innate lymphoid cells (ILC2s) are integral regulators of AT type 2 immunity, producing the cytokines interleukin-5 and IL-13, promoting eosinophils and alternatively activated macrophages, and cooperating with and promoting AT regulatory T (Treg) cells. In this review, we focus on the recent developments in our understanding of group 2 innate lymphoid cell cells and type 2 immunity in AT metabolism and homeostasis.
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