期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 137, 期 -, 页码 603-612出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2020.11.001
关键词
Trichotillomania; Skin picking disorder; Subtypes; Classification; Treatment; Mixture modeling
类别
资金
- Body-Focused Precision Medicine Initiative - TLC Foundation for Body-Focused Repetitive Behaviors
- REDCap project at the University of Chicago
- Biological Sciences Division
- Institute for Translational Medicine, CTSA grant from the National Institutes of Health [UL1 TR000430]
- Wellcome Trust Clinical Fellowship (United Kingdom) [110049/Z/15/Z]
Three subtypes of trichotillomania and two subtypes of excoriation disorder were identified, with significant differences from the control group. These clinical differences may be useful in tailoring future treatments.
Body-focused repetitive behavior disorders (BFRBs) include Trichotillomania (TTM; Hair pulling disorder) and Excoriation (Skin Picking) Disorder (SPD). These conditions are prevalent, highly heterogeneous, underresearched, and under-treated. In order for progress to be made in optimally classifying and treating these conditions, it is necessary to identify meaningful subtypes. 279 adults (100 with TTM, 81 with SPD, 40 with both TTM and SPD, and 58 controls) were recruited for an international, multi-center between-group comparison using mixture modeling, with stringent correction for multiple comparisons. The main outcome measure was to examine distinct subtypes (aka latent classes) across all study participants using item-level data from goldstandard instruments assessing detailed clinical measures. Mixture models identified 3 subtypes of TTM (entropy 0.98) and 2 subtypes of SPD (entropy 0.99) independent of the control group. Significant differences between these classes were identified on measures of disability, automatic and focused symptoms, perfectionism, trait impulsiveness, and inattention and hyperactivity. These data indicate the existence of three separate subtypes of TTM, and two separate subtypes of SPD, which are distinct from controls. The identified clinical differences between these latent classes may be useful to tailor future treatments by focusing on particular traits. Future work should examine whether these latent subtypes relate to treatment outcomes, or particular psychobiological findings using neuroimaging techniques.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据