期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 46, 期 2, 页码 281-290出版社
WILEY
DOI: 10.1002/eji.201545760
关键词
Autoantibody; B cell; Systemic lupus erythematosus (SLE); Tfh cell
类别
资金
- Centre national pour la Recherche Scientifique
- Societe Francaise de Rhumatologie and Arthritis Fondation Courtin
- NIH [U19-AI082715]
- Alliance for Lupus Research
- Lupus Research Institute
Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory autoimmune disease characterized by a breakdown of tolerance to self. The autoantibodies generated in SLE are directed against nuclear components, with which they form immune complexes (ICs). ICs play key roles in organ and tissue damage, as well as in the activation of the innate and adaptive immune system during the disease course. Therefore, it is of prime importance to understand the mechanisms responsible for the development of B cells producing these pathogenic autoantibodies. There is compelling evidence that T follicular helper (Tfh) cells play a fundamental role in this process. In this review, we will summarize the current knowledge regarding the involvement of Tfh cells in SLE pathogenesis, and discuss potential strategies to target Tfh cells and/or molecules as a therapeutic modality of SLE.
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