期刊
JOURNAL OF PHARMACY AND PHARMACOLOGY
卷 73, 期 8, 页码 1080-1091出版社
OXFORD UNIV PRESS
DOI: 10.1093/jpp/rgab049
关键词
urethane; lung cancer; sildenafil; apoptosis; PDE5
The study demonstrated that sildenafil has potential anticancer effects in urethane-induced lung cancer in BALB/c mice, by inducing cell cycle arrest, apoptosis, and inhibiting metastatic activity through regulating various proteins and pathways. It highlights the importance of future research on sildenafil as a treatment for lung cancer.
Objectives Lung cancer is one of the most frequent types of cancers that lead to death. Sildenafil is a potent inhibitor of phosphodiesterase-5 and showed potential anticancer effects, which has not yet been fully evaluated. Thus, this study aims to investigate the potential anticancer effect of sildenafil in urethane-induced lung cancer in BALB/c mice. Methods Five-week-old male BALB/c mice were treated with either (i) normal saline only, (ii) sildenafil only 50 mg kg-1/P.O every other day for the last four successive weeks, (iii) urethane 1.5 gm kg-1 i.p (at day 1 and day 60), (iv) carboplatin after urethane induction, or (v) sildenafil after urethane induction. Key findings It was shown that sildenafil significantly increased the levels of cGMP and Caspase-3 with a reduction of NF-kappa B, Bcl-2, Cyclin D1, intercellular adhesion molecule 1, matrix metalloproteinase-2 levels and normalisation of Nrf2 along with pronounced improvement in the histological patterns. Conclusions These results indicated that sildenafil markedly induces cell cycle arrest, apoptosis and inhibits the metastatic activity through activation of cyclic guanosine monophosphate/protein kinase G pathway and down-regulation of cyclin D1 and nuclear factor kappa light chain enhancer of activated B cells with downstream anti-apoptotic gene Bcl-2, which underscores the critical importance of future using sildenafil in the treatment of lung cancer.
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