4.5 Article

Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats

Yannick Fotio et al.

Summary: The study found that NAAA inhibitors can reduce voluntary alcohol intake without affecting water, food, or saccharin consumption. Additionally, NAAA inhibitors also attenuate voluntary alcohol self-administration.

PSYCHOPHARMACOLOGY (2021)

Article Anesthesiology

N-acylethanolamine-hydrolysing acid amidase: A new potential target to treat paclitaxel-induced neuropathy

Wisam Toma et al.

Summary: The study shows that paclitaxel reduces PEA levels in the spinal cord, while exogenous administration of PEA partially alleviates PIPN. Additionally, targeting NAAA enzyme with specific compound AM9053 can reverse and prevent PIPN. These findings suggest that selective NAAA inhibitors could be promising future therapeutics for the treatment and prevention of PIPN.

EUROPEAN JOURNAL OF PAIN (2021)

Article Chemistry, Medicinal

N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition

Daniele Piomelli et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Pharmacology & Pharmacy

N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritis

Pan Zhou et al.

PHARMACOLOGICAL RESEARCH (2019)

Editorial Material Medicine, General & Internal

Gabapentin for Chronic Neuropathic Pain

Andrew Moore et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Article Chemistry, Multidisciplinary

Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis

Marco Migliore et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Review Pharmacology & Pharmacy

Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy

Linda Gabrielsson et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2016)

Article Pharmacology & Pharmacy

An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freund's Adjuvant Rat Model of Arthritis

F. T. Bonezzi et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)

Article Pharmacology & Pharmacy

The anti-inflammatory effects of palmitoylethanolamide (PEA) on endotoxin-induced uveitis in rats

Daniela Impellizzeri et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2015)

Article Pharmacology & Pharmacy

Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent

Francesca Borrelli et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Article Neurosciences

A Lipid Gate for the Peripheral Control of Pain

Daniele Piomelli et al.

JOURNAL OF NEUROSCIENCE (2014)

Review Neurosciences

Peripheral gating of pain signals by endogenous lipid mediators

Daniele Piomelli et al.

NATURE NEUROSCIENCE (2014)

Review Endocrinology & Metabolism

A fatty gut feeling

Daniele Piomelli

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)

Article Multidisciplinary Sciences

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

Carlos Solorzano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Biochemistry & Molecular Biology

Receptors for acylethanolamides-GPR55 and GPR119

Grzegorz Godlewski et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2009)

Article Pharmacology & Pharmacy

Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-α

Jesse LoVerme et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

Article Biochemistry & Molecular Biology

Molecular characterization of a phospholipase D generating anandamide and its congeners

Y Okamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Activation of TRPV1 by the satiety factor oleoylethanolamide

GP Ahern

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Anesthesiology

Chemotherapy-evoked painful peripheral neuropathy

RC Polomano et al.

PAIN MEDICINE (2001)