Update on pediatric testicular germ cell tumors

Background: Testicular germ cell tumors are uncommon tumors that are encountered by pediatric sur-geons and urologists and require a knowledge of appropriate contemporary evaluation and surgical and medical management.Method: A review of the recommended diagnostic evaluation and current surgical and medical manage-ment of children and adolescents with testicular germ cell tumors based upon recently completed clinical trials was performed and summarized in this article. Results: In this summary of childhood and adolescent testicular germ cell tumors, we review the initial clinical evaluation, surgical and medical management, risk stratification, results from recent prospective cooperative group studies, and clinical outcomes. A summary of recently completed clinical trials by pe-diatric oncology cooperative groups is provided, and best surgical practices are discussed.Conclusions: Testicular germ cell tumors in children are rare tumors. International collaborations, data-sharing, and enrollment of patients at all stages and risk classifications into active clinical trials will enhance our knowledge of these rare tumors and most importantly improve outcomes of patients with testicular germ cell tumors. Level of evidence: This is a review article of previously published and referenced level 1 and 2 studies, but also includes expert opinion level 5, represented by the American Pediatric Surgical Association Cancer Committee.(c) 2021 Elsevier Inc. All rights reserved.

Automated summary

This article reviews and summarizes the diagnostic evaluation, treatment methods, and recent research findings of testicular germ cell tumors in children and adolescents. Testicular germ cell tumors are rare tumors, and global collaborations and data sharing will contribute to a better understanding of these rare tumors and improve treatment outcomes for patients.