期刊
EUROPEAN JOURNAL OF HEART FAILURE
卷 18, 期 12, 页码 1420-1429出版社
WILEY
DOI: 10.1002/ejhf.678
关键词
Heart failure; Cardiac metabolism; Metabolic therapy; Foetal switch; Energy starvation
资金
- Scientific Research Fund of Flanders (FWO) [1183211 N, 1183213 N, G074009N]
- Dutch Scientific Research Fund (NWO) [2008 N011]
- European Union [261409, 278249, 305507, 285991, 602156]
- Netherlands Cardiovascular Research Initiative, CVON-Arena
- Frans Van de Werf Fund for Clinical Cardiovascular Research (LRD, KU Leuven, Belgium)
The failing heart has an increased metabolic demand and at the same time suffers from impaired energy efficiency, which is a detrimental combination. Therefore, therapies targeting the energy-deprived failing heart and rewiring cardiac metabolism are of great potential, but are lacking in daily clinical practice. Metabolic impairment in heart failure patients has been well characterized for patients with reduced ejection fraction, and is coming of age in patients with 'preserved' ejection fraction. Targeting cardiomyocyte metabolism in heart failure could complement current heart failure treatments that do improve cardiovascular haemodynamics, but not the energetic status of the heart. In this review, we discuss the hallmarks of normal cardiac metabolism, typical metabolic disturbances in heart failure, and past and present therapeutic targets that impact on cardiac metabolism.
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