4.7 Article

Construction of gem-Difluoroenol Esters through Catalytic O-Selective Addition of Difluoroenoxysilanes to Ketenes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions

Bingnan Du et al.

Summary: The authors developed diverse 2,2-difluorovinyl benzoates as versatile building blocks for modular synthesis of gem-difluoroenol ethers and gem-difluoroalkenes using nickel-catalyzed cross coupling. The method allows for late-stage functionalization of multifunctionalized bioactive molecules due to the diversity of the building blocks and excellent functional group tolerance.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

HFIP-catalyzed direct dehydroxydifluoroalkylation of benzylic and allylic alcohols with difluoroenoxysilanes

Jinshan Li et al.

Summary: A novel method catalyzed by HFIP for the synthesis of various α,α-difluoroketones has been developed, which are important intermediates in medicinal and organic chemistry. Moreover, this method can also be applied in the late-stage dehydroxydifluoroalkylation of compounds.

CHEMICAL COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes

Xiao-Si Hu et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Multidisciplinary

Visible light promoted deaminative difluoroalkylation of aliphatic amines with difluoroenoxysilanes

Yang Huang et al.

CHEMICAL COMMUNICATIONS (2020)

Review Chemistry, Multidisciplinary

Recent advances in three-component difunctionalization ofgem-difluoroalkenes

Chi Liu et al.

CHEMICAL COMMUNICATIONS (2020)

Review Chemistry, Multidisciplinary

Transition-Metal-Mediated and -Catalyzed C-F Bond Activation by Fluorine Elimination

Takeshi Fujita et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Chemistry, Multidisciplinary

The ortho-Difluoroalkylation of Aryliodanes with Enol Silyl Ethers: Rearrangement Enabled by a Fluorine Effect

Xin Huang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Chemistry, Organic

Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates

Haibo Mei et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2019)

Article Chemistry, Organic

A Sc(OTf)3 catalyzed Mukaiyama-Mannich reaction of difluoroenoxysilanes with unactivated ketimines

Xiao-Si Hu et al.

ORGANIC CHEMISTRY FRONTIERS (2019)

Review Chemistry, Multidisciplinary

Catalytic selective mono- and difluoroalkylation using fluorinated silyl enol ethers

Xiao-Si Hu et al.

CHEMICAL COMMUNICATIONS (2019)

Review Chemistry, Multidisciplinary

Picking One out of Three: Selective Single C-F Activation in Trifluoromethyl Groups

Florian Jaroschik

CHEMISTRY-A EUROPEAN JOURNAL (2018)

Review Chemistry, Organic

Methods for the Synthesis of ,-Difluoroketones

Graham Pattison

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2018)

Article Chemistry, Medicinal

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

Nicholas A. Meanwell

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Organic

Testing the veracity of claims of Lewis acid catalysis

Ivan Solic et al.

TETRAHEDRON LETTERS (2018)

Review Chemistry, Multidisciplinary

Influence of C-F•••H-X Interactions on Organic Reactions

Hao Yong-Jia et al.

ACTA CHIMICA SINICA (2018)

Article Chemistry, Organic

Recent advances in the synthesis and C-F functionalization of gem-difluoroalkenes

Xuxue Zhang et al.

TETRAHEDRON LETTERS (2017)

Article Chemistry, Multidisciplinary

Exploiting the unusual effects of fluorine in methodology

Douglas L. Orsi et al.

CHEMICAL COMMUNICATIONS (2017)

Review Chemistry, Multidisciplinary

Highly Stereoselective Gold-Catalyzed Coupling of Diazo Reagents and Fluorinated Enol Silyl Ethers to Tetrasubstituted Alkenes

Fu-Min Liao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Chemistry, Multidisciplinary

Visible-light-initiated difluoromethylation of arene diazonium tetrafluoroborates

Ye-bin Wu et al.

CHEMICAL COMMUNICATIONS (2016)

Review Chemistry, Multidisciplinary

The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations

Chuanfa Ni et al.

CHEMICAL SOCIETY REVIEWS (2016)

Article Chemistry, Multidisciplinary

Stereo- and Chemodivergent NHC-Promoted Functionalisation of Arylalkylketenes with Chloral

James J. Douglas et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

Review Chemistry, Organic

Fluorinated enol ethers: their synthesis and reactivity

M. Decostanzi et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

Article Chemistry, Organic

Highly Enantioselective Michael Addition of 2-Fluoro-1,3-diketones to Nitroalkenes

Jacek Kwiatkowski et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

Highly Efficient On Water Catalyst-Free Nucleophilic Addition Reactions Using Difluoroenoxysilanes: Dramatic Fluorine Effects

Jin-Sheng Yu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Review Chemistry, Multidisciplinary

Introduction of Fluorine and Fluorine-Containing Functional Groups

Theresa Liang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Review Chemistry, Multidisciplinary

Ketenes and Other Cumulenes as Reactive Intermediates

Annette D. Allen et al.

CHEMICAL REVIEWS (2013)

Article Chemistry, Multidisciplinary

Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles

Yun-Lin Liu et al.

CHEMICAL COMMUNICATIONS (2012)

Review Chemistry, Multidisciplinary

Synthesis and Metal-Catalyzed Reactions of gem-Dihalovinyl Systems

Giorgio Chelucci

CHEMICAL REVIEWS (2012)

Article Chemistry, Organic

Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

Edward Richmond et al.

ORGANIC LETTERS (2012)

Article Chemistry, Inorganic & Nuclear

Impact of Silyl Enol Ether Stability on Palladium-Catalyzed Arylations

Yong Guo et al.

ORGANOMETALLICS (2010)

Review Chemistry, Multidisciplinary

C-F Bond Activation in Organic Synthesis

Hideki Amii et al.

CHEMICAL REVIEWS (2009)

Article Chemistry, Applied

Asymmetric Dimerization of Disubstituted Ketenes Catalyzed by N-Heterocyclic Carbenes

Hui Lv et al.

ADVANCED SYNTHESIS & CATALYSIS (2008)

Review Chemistry, Multidisciplinary

Understanding organofluorine chemistry. An introduction to the C-F bond

David O'Hagan

CHEMICAL SOCIETY REVIEWS (2008)

Review Chemistry, Multidisciplinary

Fluorine in medicinal chemistry

Sophie Purser et al.

CHEMICAL SOCIETY REVIEWS (2008)

Review Multidisciplinary Sciences

Fluorine in pharmaceuticals:: Looking beyond intuition

Klaus Mueller et al.

SCIENCE (2007)

Article Chemistry, Inorganic & Nuclear

Preparation of 1-aryl-2,2-difluoro enol esters via dehydrosulfonylation of α-(phenylsulfonyl)difluoromethylated benzoates

Laijun Zhang et al.

JOURNAL OF FLUORINE CHEMISTRY (2007)

Article Chemistry, Inorganic & Nuclear

Fluoro-artemisinins:: When a gem-difluoroethylene replaces a carbonyl group

Guillaume Magueur et al.

JOURNAL OF FLUORINE CHEMISTRY (2006)

Article Chemistry, Multidisciplinary

Synthesis of highly substituted N-hydroxyindoles through 1,5-addition of carbon nucleophiles to in situ generated unsaturated nitrones

K. C. Nicolaou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)

Article Chemistry, Medicinal

Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases

P Van der Veken et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Review Chemistry, Multidisciplinary

The first century of ketenes (1905-2005): The birth of a versatile family of reactive intermediates

TT Tidwell

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

Article Chemistry, Multidisciplinary

Evidence that protons can be the active catalysts in Lewis acid mediated hetero-Michael addition reactions

TC Wabnitz et al.

CHEMISTRY-A EUROPEAN JOURNAL (2004)

Article Chemistry, Organic

Fluoro artemisinins:: Difluoromethylene ketones

F Chorki et al.

JOURNAL OF ORGANIC CHEMISTRY (2001)