期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 10, 页码 7280-7287出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00505
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资金
- Max-Planck Society
Galactofurans are identified as crucial elements in the structure of Mycobacteria's envelopes, with thioglycoside building blocks playing a key role in the automated glycan assembly of long linear galactofuranosides. Among these building blocks, benzoylated galactofuranose thioglycoside has been proven to be the most efficient for oligosaccharide construction.
Galactofurans are an important structural constituent of arabinogalactan and lipopolysaccharides (LPS) ubiquitously present on the envelopes of all Mycobacteria. Key to the automated glycan assembly (AGA) of linear galactofuranosides as long as 20-mers was the identification of thioglycoside building blocks with a fine balance of stereoelectronic and steric effects to ensure the stability of oligogalactofuranoside during the synthesis. A benzoylated galactofuranose thioglycoside building block proved most efficient for oligosaccharide construction.
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