4.7 Article

Direct Synthesis of N-Difluoromethyl-2-pyridones from Pyridines

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Metal-Free Difunctionalization of Pyridines: Selective Construction of N-CF2H and N-CHO Dihydropyridines

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Summary: The reactivity of N-difluoromethylpyridinium salts is rarely explored due to their instability and low availability. However, a novel nucleophilic addition reaction has been developed to efficiently synthesize N-CF2H-dihydropyridines and N-CHO-dihydropyridines with good functional group tolerance and yields ranging from good to excellent.

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