4.7 Article

Electrochemical and Photocatalytic Oxidative Coupling of Ketones via Silyl Bis-enol Ethers

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JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 9, 页码 6600-6611

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AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00384

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  1. National Institutes of Health [NIHGMS 1R01GM124089]
  2. Air Force Office of Scientific Research [FA9550-20-1-0364]

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The diastereoselective oxidative coupling of ketones through a silyl bis-enol ether intermediate by anodic and photocatalytic oxidation is reported in this study. These methods offer several 1,4-diketones in good yields without the need for stoichiometric metal oxidants. The strategic use of a silicon tether enables the coupling of both aromatic and aliphatic ketones as well as the synthesis of quaternary centers.
Diastereoselective oxidative coupling of ketones through a silyl bis-enol ether intermediate by anodic and photocatalytic oxidation is reported. These methods provide several 1,4-diketones in good yields without the need for stoichiometric metal oxidants. The strategic use of a silicon tether enables the coupling of both aromatic and aliphatic ketones as well as the synthesis of quaternary centers. Cyclic voltammetry is used to gain insight into the oxidation events of the reaction.

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