Chromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols

We describe an aerobic intramolecular dearomative coupling reaction of tethered phenols using a catalytic system consisting of a chromium-salen (Cr-salen) complex combined with a nitroxyl radical. This novel catalytic system enables formation of various spirocyclic dienone products including those unable to be accessed by previously reported methods efficiently under mild reaction conditions.

Automated summary

The study presents a novel catalytic system for an aerobic intramolecular dearomative coupling reaction using a chromium-salen complex and a nitroxyl radical. This system enables the formation of various spirocyclic dienone products under mild reaction conditions, including those previously inaccessible by efficient methods.