期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 7, 页码 5183-5196出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00080
关键词
-
资金
- National Institutes of Health [R01GM121660]
The C-H activation/annulation reaction of benzamides with fluoroalkylated alkynes in the presence of a Co(acac)(2)center dot 2H(2)O catalyst resulted in the formation of 3- and 4-fluoroalkylated isoquinolinones with high yields and regioselectivities of approximately 70%. These regioisomers were successfully separated and obtained in pure form, with X-ray crystallographic analyses confirming the major or minor regioisomers as 4- or 3-fluoroalkylated isoquinolinones, respectively.
The C-H activation/annulation reaction of various benzamides with fluoroalkylated alkynes in the presence of a Co(acac)(2)center dot 2H(2)O catalyst proceeded very smoothly to give the corresponding 3- and 4-fluoroalkylated isoquinolinones in excellent yields with approximately 70% regioselectivities. These regioisomers could be successfully separated and obtained in pure form. Major or minor regioisomers were determined as 4- or 3-fluoroalkylated isoquinolinones, respectively, based on X-ray crystallographic analyses.
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