Diastereoselective Formal Synthesis of Polycyclic Meroterpenoid (±)-Cochlearol A

A formal synthesis of (+/-)-cochlearol A was accomplished. The synthesis features Suzuki coupling and Friedel-Crafts cyclization as a convergent strategy to the functionalized tetralone ring and an intramolecular construction of the C/D ring involving sequential epoxide formation/acetal formation.

Automated summary

The formal synthesis of (+/-)-cochlearol A was achieved using Suzuki coupling and Friedel-Crafts cyclization as a convergent strategy to functionalize the tetralone ring, and an intramolecular construction of the C/D ring involving sequential epoxide formation/acetal formation.