期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 94, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2021.108751
关键词
Olive oil; soybean oil; coconut oil; microbiota; inflammation; mitochondrial function; insulin sensitivity; hepatic steatosis
资金
- Consejo Nacional de Ciencia y Tecnologia (CONACYT)
The study showed that consuming soybean oil rich in polyunsaturated fats benefits gut microbiota diversity, increases insulin sensitivity, and reduces inflammation. Meanwhile, consuming olive oil rich in monounsaturated fats increases Bifidobacterium levels, enhances fatty acid oxidation, and decreases inflammation.
Diets rich in mono or polyunsaturated fats have been associated with a healthy phenotype, but there is controversial evidence about coconut oil (CO), which is rich in saturated medium-chain fatty acids. Therefore, the purpose of the present work was to study whether different types of oils rich in polyun-saturated (soybean oil, SO), monounsaturated (olive oil, OO), or saturated fatty acids (coconut oil, CO) can regulate the gut microbiota, insulin sensitivity, inflammation, mitochondrial function in wild type and PPAR alpha KO mice. The group that received SO showed the highest microbial diversity, increase in Akkermansia muciniphila, high insulin sensitivity and low grade inflammation, The OO group showed similar insulin sensitivity and insulin signaling than SO, increase in Bifidobacterium, increase in fatty acid oxidation and low grade inflammation. The CO consumption led to the lowest bacterial diversity, a 9-fold increase in the LPS concentration leading to metabolic endotoxemia, hepatic steatosis, increased lipogenesis, highest LDL-cholesterol concentra-tion and the lowest respiratory capacity and fatty acid oxidation in the mitochondria. The absence of PPAR alpha decreased alpha diversity and increased LPS concentration particularly in the CO group, and increased insulin sensitivity in the groups fed SO or OO. These results indicate that consuming mono or polyunsaturated fatty acids produced health benefits at the recommended intake but a high concentration of oils (three times the recommended oil intake in rodents) significantly decreased the microbial alpha-diversity independent of the type of oil. (C) 2021 Elsevier Inc. All rights reserved.
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