Copper-containing bioactive glass/PVA membranes for guided bone regeneration

The purpose of this paper was to produce CuO-containing bioactive glass/PVA membranes with osteogenic and antibacterial properties to use as a membrane barrier for guided bone regeneration (GBR). The composite membranes were obtained by aqueous tape casting using PVA and a sol-gel-derived bioactive glass composed of 60% SiO2 center dot(36-x)% CaO center dot 4% P2O5 center dot x% CuO (mol %), where x = 0, 1 and 3%. The tape casting process could not show changes either in the composition of the glass or in its structure. When immersed in SFB, all composite membranes showed ability to form an apatite layer. The presence of CuO in the membranes improved the osteoblastic proliferation along with a higher damage to the bacteria membrane. Considering their low swelling rate, important surface bioactivity and low level degradation over time, these membranes meet the basic requirements to act as a GBR barrier, while demonstrating a high ability to control the bacteria growth.

Automated summary

The study aimed to produce CuO-containing bioactive glass/PVA membranes with osteogenic and antibacterial properties for guided bone regeneration. The composite membranes showed ability to form an apatite layer in simulated body fluid, improved osteoblastic proliferation, and higher damage to bacteria. These membranes have low swelling rate, important surface bioactivity, and low degradation over time, meeting the basic requirements for GBR barriers while effectively controlling bacterial growth.