期刊
JOURNAL OF NEUROVIROLOGY
卷 27, 期 3, 页码 422-433出版社
SPRINGER
DOI: 10.1007/s13365-021-00965-1
关键词
Cocaine; HIV; Iowa Gambling Task (IGT); Decision-Making
资金
- Chicago Developmental Center for AIDS Research (D-CFAR), a National Institutes of Health (NIH) [P30 AI 082151]
The study found that cocaine dependence significantly impacted overall IGT performance. Individuals who were HIV-positive tended to have less total money at the end of the game, indicating a focus on short-term gains rather than long-term rewards.
Our study aimed to understand the impact of cocaine dependence on high-risk decision-making abilities in individuals with the human immunodeficiency virus (HIV) and individuals with cocaine dependence. We recruited 99 participants (27 HIV/Cocaine, 20 HIV Only, 26 Cocaine Only, and 26 Healthy Controls). The Iowa Gambling Task (IGT) was applied to assess decision-making abilities. Independent and interactive effects of HIV status and cocaine dependence were examined using 2 x 2 factorial ANCOVA with premorbid IQ (WRAT-4: WR) as the covariate. We found cocaine dependence had a significant adverse effect on overall IGT performance (p = 0.015). We also found individuals who were HIV-positive tended to have less total money at the end of the game than individuals who were HIV-negative (p = 0.032), suggesting individuals living with HIV had less focus on long-term gains and more focus on short-term gains. Our findings highlight the significant impact of cocaine dependence on decision-making abilities and the difficulty individuals with HIV have in adequately weighing the cost and benefits of their decisions and making appropriate changes for the future.
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