期刊
JOURNAL OF NEUROSCIENCE
卷 41, 期 20, 页码 4500-4513出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2039-20.2021
关键词
addiction; aversion; avoidance; chemogenetics; reward; ultrasonic vocalizations
资金
- National Institutes of Health [F99NS120641, F31DA048578, T32NS045540, R00DA035251, P50DA044118, R21MH118748, R01DA036612]
- Canadian Institutes of Health Research Grant [PJT-162444]
Through chemogenetic inhibition of VPGABA neurons, it has been demonstrated that these neurons play a critical role in high-stakes decision-making, leading rats to prefer a safe small reward over a risky large reward.
Pursuing rewards while avoiding danger is an essential function of any nervous system. Here, we examine a new mechanism helping rats negotiate the balance between risk and reward when making high-stakes decisions. Specifically, we focus on GABA neurons within an emerging mesolimbic circuit nexus: the ventral pallidum (VP). These neurons play a distinct role from other VP neurons in simple motivated behaviors in mice, but their role in more complex motivated behaviors is unknown. Here, we interrogate the behavioral functions of VPGABA neurons in male and female transgenic GAD1:Cre rats (and WT littermates), using a reversible chemogenetic inhibition approach. Using a behavioral assay of risky decision-making, and of the food-seeking and shock-avoidance components of this task, we show that engaging inhibitory Gi/o signaling specifi-cally in VPGABA neurons suppresses motivation to pursue highly salient palatable foods, and possibly also motivation to avoid being shocked. In contrast, inhibiting these neurons did not affect seeking of low-value food, free consumption of palatable food, or unconditioned affective responses to shock. Accordingly, when rats considered whether to pursue food despite poten-tial for shock in a risky decision-making task, inhibiting VPGABA neurons caused them to more readily select a small but safe reward over a large but dangerous one, an effect not seen in the absence of shock threat. Together, results indicate that VPGABA neurons are critical for high-stakes adaptive responding that is necessary for survival, but which may also malfunc-tion in psychiatric disorders.
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