4.6 Review

Sleep disturbance in movement disorders: insights, treatments and challenges

期刊

出版社

BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp-2020-325546

关键词

movement disorders; sleep; sleep disorders

资金

  1. European Social Fund
  2. Cardiff University
  3. MRC Clinician-Scientist Fellowship [MR/P008593/1]
  4. KESS2
  5. MRC [MR/P008593/1] Funding Source: UKRI

向作者/读者索取更多资源

Sleep and circadian rhythm disturbances are central features of many movement disorders, with implications for early disease detection. Medication for motor symptoms can impact sleep, highlighting the importance of addressing sleep disturbances for improved quality of life. Shared underlying mechanisms between motor and sleep pathophysiology warrant further investigation for better understanding and management of movement disorders.
Sleep and circadian rhythm disturbances are central features of many movement disorders, exacerbating motor and non-motor symptoms and impairing quality of life. Understanding these disturbances to sleep is clinically important and may further our understanding of the underlying movement disorder. This review evaluates the current anatomical and neurochemical understanding of normal sleep and the recognised primary sleep disorders. In addition, we undertook a systematic review of the evidence for disruption to sleep across multiple movement disorders. Rapid eye movement sleep behaviour disorder has emerged as the most reliable prodromal biomarker for the alpha synucleinopathies, including Parkinson's disease and multiple system atrophy, often preceding motor symptom onset by several years. Abnormal sleep has also been described for many other movement disorders, but further evidence is needed to determine whether this is a primary or secondary phenotypic component of the underlying condition. Medication used in the treatment of motor symptoms also affects sleep and can aggravate or cause certain sleep disorders. Within the context of movement disorders, there is also some suggestion of a shared underlying mechanism for motor and sleep pathophysiology, with evidence implicating thalamic and brainstem structures and monoaminergic neurotransmission. This review highlights the need for an understanding of normal and abnormal sleep within the movement disorder clinic, an ability to screen for specific causes of poor sleep and to treat sleep disturbance to improve quality of life. Key sleep disorders also act as important biomarkers and have implications in diagnosis, prognosis and the development of future therapies.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据