The identification, development and therapeutic potential of IL-10-producing regulatory B cells in multiple sclerosis

Regulatory B cells are a rare B-cell subset widely known to exert their immunosuppressive function via the production of interleukin-10 (IL-10) and other mechanisms. B10 cells are a special subset of regulatory B cells with immunoregulatory function that is fully attributed to IL-10. Their unique roles in the animal model of multiple sclerosis (MS) have been described, as well as their relevance in MS patients. This review specifically focuses on the identification and development of B10 cells, the signals that promote IL-10 production in B cells, the roles of B10 cells in MS, and the potential and major challenges of the application of B10-based therapies for MS.

Automated summary

This review focuses on the unique roles of immunoregulatory B10 cells in multiple sclerosis (MS), including their identification and development, signals that promote IL-10 production, and the potential and challenges of B10-based therapies for MS.