期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 353, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2021.577522
关键词
Adrenocorticotropic hormone; Proopiomelanocortin; B lymphocytes; Immunity
Research suggests that the direct effects of repository corticotropin injection on human B cells may require complementary signals from multiple components of the preparation.
Repository corticotropin injection (RCI), a complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides, has been found to suppress key aspects of gene expression and cellular function in human B lymphocytes in vitro. The present studies reveal that neither individual POMC peptides (alpha-MSH, ACTH(1-39), ACTH(1-24), beta-endorphin) nor other related pituitary neuropeptides are sufficient to elicit these effects, even though specific receptors capable of transmitting signals from these peptides are expressed by human B cells. RCI's direct effects on human B cells may require complementary signals from multiple components of the preparation.
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