期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 357, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2021.577598
关键词
Autoimmune encephalitis; Neuronal surface antibodies; Incidence; Epidemiology; LGI1; NMDAR
This study reviewed 13 years of biobank data to assess the incidence of NSAE in two Italian provinces over a 5-year period, finding an estimated rate of 1.54 per 1,000,000 population. LGI1-E was the most common NSAE among adults.
Epidemiologic data on neuronal surface antibody (NSAb)-associated autoimmune encephalitides (NSAE) are scarce and heterogeneous. We review our 13-year-long biobank-data collection and provide the incidence of NSAE in two Italian provinces (approx. Population of 1,400,000) over a 5-year period (July 2013-June 2018). NSAbs were diagnosed in 75 out of 1179 tested patients (6.4%). The most common NSAbs were anti-LGI1 (30 cases), followed by NMDAR (24). Eleven cases of NSAE were diagnosed in Treviso and Trento provinces with an estimated incidence of 1.54 per 1,000,000 population (LGI1-encephalitis 0.84; C.I. 0.38-1.88). LGI1-E is the most frequent NSAE among adults.
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