Neuroimmune metabolism: Uncovering the role of metabolic reprogramming in central nervous system disease

The rapidly expanding field of immunometabolism has highlighted an intricate association between the metabolic pathways that program cellular pro-inflammatory versus anti-inflammatory activity. This Special Issue on Neuroimmune Metabolism showcases a growing body of work characterizing the metabolic profiles of the major CNS-resident and peripheral immune cell players in neuroinflammation, neurodegeneration, and brain injury. The review articles address the roles of glycolytic, oxidative, and lipid metabolism that are associated with beneficial or detrimental properties in various neurological conditions, address unanswered questions in the field, and discuss promising avenues for future therapeutics.

Automated summary

The rapidly expanding field of immunometabolism has unveiled a complex association between cellular pro-inflammatory and anti-inflammatory activity, showcasing the metabolic profiles of immune cells in neuroinflammation. The review articles in this Special Issue address the roles of different metabolism types in various neurological conditions and discuss potential therapeutic avenues for the future.