Ferroptosis: An emerging therapeutic target in stroke

Stroke is a disastrous neurological disease with high morbidity and mortality. The mechanism of the pathological process is extremely complicated and unclear. Although many basic studies have confirmed molecular mechanism of brain injury after stroke, these studies have not yet translated into treatment and clinical application. Ferroptosis is a form of cell death that is distinct from necrosis, apoptosis, and autophagy morphologically and biochemically and is characterized by iron-dependent accumulation of lipid peroxides. Despite ferroptosis being first identified in cancer cells, it was recently revealed to also be a significant factor in the pathological process of stroke. A better understanding of ferroptosis in stroke may provide us with better therapeutic targets to treat this devastating disease. Here, we systematically summarized the current mechanism of ferroptosis and reviewed the current studies regarding the relationship between ferroptosis and stroke.

Automated summary

Stroke is a devastating neurological disease with high morbidity and mortality, and the mechanism of its pathological process remains unclear. Ferroptosis, a distinct form of cell death characterized by iron-dependent accumulation of lipid peroxides, has been shown to play a significant role in the pathological process of stroke.Understanding the relationship between ferroptosis and stroke may provide better therapeutic targets for treating this devastating disease.