期刊
JOURNAL OF NEURAL ENGINEERING
卷 18, 期 4, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1741-2552/abf892
关键词
retinal prosthesis; photoelectric dye; boundary value problem; biophysical models of retinal cells
资金
- Japan Society for the Promotion of Science (JSPS) KAKENHI [JP19J13826]
The study explored how the OUReP affects retinal tissues through modeling, indicating that this retinal prosthesis is likely capable of eliciting responses in retinal bipolar cells necessary to generate vision under most ambient conditions.
Objective. Retinal prostheses have been developed to restore vision in blind patients suffering from diseases like retinitis pigmentosa. Approach. A new type of retinal prosthesis called the Okayama University-type retinal prosthesis (OUReP) was developed by chemically coupling photoelectric dyes to a polyethylene film surface. The prosthesis works by passively generating an electric potential when stimulated by light. However, the neurophysiological mechanism of how OUReP stimulates the degenerated retina is unknown. Main results. Here, we explore how the OUReP affects retinal tissues using a finite element model to solve for the potential inside the tissue and an active Hodgkin-Huxley model based on rat vision to predict the corresponding retinal bipolar response. Significance. We show that the OUReP is likely capable of eliciting responses in retinal bipolar cells necessary to generate vision under most ambient conditions.
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