期刊
JOURNAL OF NATURAL MEDICINES
卷 75, 期 4, 页码 840-853出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-021-01526-w
关键词
Asphodelus microcarpus; Aloe-emodin; Anti-cancer; Breast cancer; Metastasis; NF-κ B
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [17H06398]
- Cooperative Research Project from the Institute of Natural Medicine, University of Toyama
- OTSUKA Toshimi Scholarship Foundation [20-70]
- Grants-in-Aid for Scientific Research [17H06398] Funding Source: KAKEN
Aloe-emodin and emodic acid can control the migratory and invasive ability of breast cancer cells, inhibit NF-kappa B activity, and the expression of its downstream target molecules.
Anthraquinones are a major class of compounds naturally occurring in Asphodelus microcarpus. The pharmacological actions of anthraquinones in cancer cells are known to induce apoptosis or autophagy, and revert multidrug resistance. In this study, five anthraquinone-type analogs were isolated from the methanol extract of A. microcarpus leaves and identified as, emodin, rhein, physcion, aloe-emodin, and emodic acid. Among them, aloe-emodin and emodic-acid strongly inhibited the proliferation, cells-intrinsic NF-kappa B activity and metastatic ability of breast cancer. Although aloe-emodin inhibited p38 and ERK phosphorylation, emodic-acid more markedly inhibited JNK, in addition to p38 and ERK phosphorylation. Both aloe-emodin and emodic-acid inhibited the secretion of the pro-tumorigenic cytokines IL-1 beta and IL-6, and VEGF and MMP expression, and subsequently inhibited the invasive and migratory potential of 4T1 cells. Thus, our study demonstrated the effects of aloe-emodin and emodin-acid in controlling the migratory and invasive ability of 4T1 breast cancer cells, in addition to inhibiting NF-kappa B activity and the expression of its downstream target molecules.
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