期刊
JOURNAL OF MOLECULAR LIQUIDS
卷 327, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molliq.2020.114840
关键词
Tartaric acid; Chiral separation; Ionic liquid; Chiral selector; Capillary electrophoresis
资金
- Project of National Natural Science Foundation of China [81703465]
- Natural Science Foundation of Jiangsu Province [BK20170533]
This study introduces a systematic approach to improve the enantioseparation performance of tartaric acid in capillary electrophoresis using ionic liquid technology. It found that achiral ILs exhibit better performance when combined with tartaric acid compared to chiral ILs.
This work presents, for the first time, a systematic and step-by-step methodology on how to improve the enantioseparation performance of tartaric acid (TT) in capillary electrophoresis (CE) using ionic liquid (IL) technology. A series of chiral and achiral ILs were applied in different separation modes to evaluate their influence on TT's enantioselectivity. Unlike previous ILs-related chiral CE studies, which typically report positive synergistic effect, in this work, negative synergistic effect was observed between TT and most chiral ILs (including several amino acids ILs and a saccharide-based IL). Instead, achiral ILs (the precursors of chiral ILs, mainly tetraalkylammonium hydroxides) exhibited significantly better performance in system modifications when used in combination with TT. The influence of the configuration of TT and chiral ILs on enantioseparation was investigated to explore the synergistic mechanism. The result showed that the existence of the chiral part of the ILs may cause interference rather than facilitation in the selector-select and interactions. On the basis of the above results, we further designed a novel TT-based IL-type chiral selector, di-tetramethylammonium-D-tartrate ((TMA)2-D-TT). It is able to achieve excellent enantioseparation of all model analytes without adding any other chiral or achiral additives. This study demonstrates that TTs, which have almost been abandoned in chiral CE, are still able to provide satisfactory enantioselectivities with the help of ILs. In some application modes, e.g., under the achiral ILs modification or using TT-based ILs, their chiral separation performance is comparable or even superior to the well-established and widely used TT ester-type chiral selectors (C) 2020 Elsevier B.V. All rights reserved.
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