4.7 Article

A comparison of charge-transfer complexes of iodine with some antibiotics formed through two different approaches (liquid-liquid vs solid-solid)

期刊

JOURNAL OF MOLECULAR LIQUIDS
卷 329, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.molliq.2021.115560

关键词

Charge-transfer reaction; Iodine; Antibiotics; Tri-iodide ion; Liquid-liquid interaction; Solid-solid interaction

资金

  1. Taif University Researchers Supporting Project, Taif University, Taif, Saudi Arabia [TURSP-2020/02]

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This study compared iodine CT complexes obtained from liquid and solid starting materials, finding that the solid-solid approach is faster, simpler, and does not require a purification process or consume large amounts of solvent or time. Additionally, the solid-solid approach can generate iodine CT complexes with compounds that have very low solubility in suitable organic solvents.
In this work, we compare CT complexes obtained from liquid starting materials to those generated in solid form. Specifically, iodine was complexed with four pharmaceutical compounds: trimethoprim (TMP), moxifloxacin (MOX), ceftriaxone (CTX), and sulfamethoxazole (SMZ). The synthesis approaches differed only by the phase of the starting materials (liquid-liquid vs solid-solid). The solid-solid approach successfully yielded the remaining three iodine CT complexes, which formed via a tri-iodide complex formulated as [D center dot I+]I-3(-) (D: investigated pharmaceutical compound). Comparing the two approaches, we found that the solid-solid approach is faster, simpler, doesn't require a purification process, and does not consume large amounts of solvent or time relative to its liquid-liquid counterpart. More interesting, the solid-solid approach can generate iodine CT complexes with compounds that are very poorly soluble in a suitable organic solvent, which cannot be produced using the liquid-liquid approach. (C) 2021 Elsevier B.V. All rights reserved.

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