期刊
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
卷 55, 期 2, 页码 -出版社
ELSEVIER TAIWAN
DOI: 10.1016/j.jmii.2021.05.002
关键词
Pulmonary cryptococcosis; Chinese-made; Cryptococcal glucurono-xylomannan antigen test; HIV-Negative
This study presented the performance of a Chinese-made cryptococcal GXM antigen test in the HIV-negative Chinese population. The test showed high sensitivity and specificity and demonstrated a positive correlation between serum GXM antigen levels and pulmonary lesion size.
Background: We presented the performance of a Chinese-made cryptococcal glucuronoxylomannan (GXM) antigen test using serum and bronchoalveolar lavage fluid (BALF) samples in the HIV-negative Chinese population.Methods: Between February 2017 and January 2019, HIV-negative patients with pulmonary cryptococcosis were recruited and followed-up every three months, including completion of a chest CT examination and collection of serum and BALF samples.Results: Here, thirty-seven confirmed and ten clinically diagnosed patients were recruited. Furthermore, samples from 174 noncryptococcosis patients that may cause false positives were also collected. The sensitivity of a lateral flow assay (LFA) for detecting cryptococcal GXM antigen in serum and BALF samples from confirmed cases was 97% and 95%, respectively, and the specificity was 98.2% and 93%, respectively, and the differences in these values between the BALF and serum samples were not significant. The serum cryptococcal GXM antigen value showed a positive correlation (r: 0.581, p < 0.001) with pulmonary lesion size, while the BALF value showed no correlation (r: 0.253, p: 0.13). The positivity rate of BALF was higher than that of serum when the diameter of the pulmonary lesion was small (diameter less than 20 mm). Moreover, the serum cryptococcal GXM antigen levels showed an overall decreasing trend with the decrease in pulmonary lesion size after antifungal therapy in patient follow-up.Conclusions: The Chinese-made cryptococcal GXM antigen test has better sensitivity and
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