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Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils
Henry Rosen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Activity-based protein profiling: From enzyme chemistry
Benjamin F. Cravatt et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2008)
Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model
Uta Schurigt et al.
BIOLOGICAL CHEMISTRY (2008)
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K
Jacques Yves Gauthier et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Cysteine protease cathepsin X modulates immune response via activation of β2 integrins
Natasa Obermajer et al.
IMMUNOLOGY (2008)
Cathepsin B is involved in the trafficking of TNF-α-containing vesicles to the plasma membrane in macrophages
Soon-Duck Ha et al.
JOURNAL OF IMMUNOLOGY (2008)
Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: Determinants of potency and in vivo efficacy and safety
Beth A. Connolly et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
Rachel A. Hanna et al.
NATURE (2008)
The proteolytic activity of the paracaspase MALT1 is key in T cell activation
Fabien Rebeaud et al.
NATURE IMMUNOLOGY (2008)
Cathepsin K-dependent Toll-like receptor 9 signaling revealed in experimental arthritis
Masataka Asagiri et al.
SCIENCE (2008)
Phase II trial of single agent Val-boroPro (Talabostat) inhibiting fibroblast activation protein in patients with metastatic colorectal cancer
Kalyani Narra et al.
CANCER BIOLOGY & THERAPY (2007)
Talabostat
Charles Casey Cunningham
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2007)
Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer
Katherine M. Bell-McGuinn et al.
CANCER RESEARCH (2007)
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1β and IL-18
Woods Wannamaker et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
A novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-κB activation by API2•MALT1 fusions
Heidi Noels et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
LMP2-specific inhibitors: Chemical genetic tools for proteasome biology
Yik Khuan (Abby) Ho et al.
CHEMISTRY & BIOLOGY (2007)
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1
Kei Ohnuma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain
Kelly B. Sexton et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Substrate activity screening (SAS): a general procedure for the preparation and screening of a fragment-based non-peptidic protease substrate library for inhibitor discovery
Andrew W. Patterson et al.
NATURE PROTOCOLS (2007)
Reactivity and selectivity in the inhibition of elastase by 3-oxo-beta-sultams and in their hydrolysis
Wing-Yin Tsang et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2007)
Identification of selective, nonpeptidic nitrile inhibitors of cathepsin S using the substrate activity screening method
Andrew W. Patterson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis
Dong Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Structure- and fragment-based approaches to protease inhibition
Sherida L. Johnson et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity
JP Falgueyret et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Substrate activity screening: A fragment-based method for the rapid identification of nonpeptidic protease inhibitors
WJL Wood et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes - Potential importance of selectivity over dipeptidyl peptidases 8 and 9
GR Lankas et al.
DIABETES (2005)
Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma
P Farinha et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Discovery and preclinical profile of saxagliptin (BMS-477118): A highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
DJ Augeri et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-β-sultams
WY Tsang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
IFN-γ-induced immune adaptation of the proteasome system is an accelerated and transient response
S Heink et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin
MS Buzza et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Activity-based probes that target diverse cysteine protease families
D Kato et al.
NATURE CHEMICAL BIOLOGY (2005)
Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells
S Mahrus et al.
CHEMISTRY & BIOLOGY (2005)
High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays
DN Gosalia et al.
MOLECULAR & CELLULAR PROTEOMICS (2005)
Characterization of IDN-6556(3-{2-(2-tert-butylphenylaminooxalyl)amino]-propionylamino}-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic Acid): a liver-targeted caspase inhibitor
NC Hoglen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
A dynamic role of HAUSP in the p53-Mdm2 pathway
MY Li et al.
MOLECULAR CELL (2004)
Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1,-3,-6, and-8
KE James et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Neutrophil extracellular traps kill bacteria
V Brinkmann et al.
SCIENCE (2004)
PT-100, a small molecule dipeptidyl peptidase inhibitorg has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism
S Adams et al.
CANCER RESEARCH (2004)
Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site
T Moldoveanu et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Regulation of NF-κB-dependent lymphocyte activation and development by paracaspase
AA Ruefli-Brasse et al.
SCIENCE (2003)
Non-apoptotic functions of caspases in cellular proliferation and differentiation
C Schwerk et al.
BIOCHEMICAL PHARMACOLOGY (2003)
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine:: A potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
EB Villhauer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues:: Discovery of potent water-soluble calpain inhibitors with oral bioavailability
W Lubisch et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes
D Leung et al.
NATURE BIOTECHNOLOGY (2003)
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII
B Leiting et al.
BIOCHEMICAL JOURNAL (2003)
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity
L Salmena et al.
GENES & DEVELOPMENT (2003)
Differential requirement for Malt1 in T and B cell antigen receptor signaling
J Ruland et al.
IMMUNITY (2003)
Peptide microarrays for the determination of protease substrate specificity
CM Salisbury et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
HJ Chun et al.
NATURE (2002)
Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry
Y Nakayama et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
D Greenbaum et al.
CHEMISTRY & BIOLOGY (2000)
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries
JL Harris et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
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