相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Randomized phase 2 trial of pevonedistat plus azacitidine versus azacitidine for higher-risk MDS/CMML or low-blast AML
Mikkael A. Sekeres et al.
LEUKEMIA (2021)
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction
Wenjuan Zhou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML
Ronan T. Swords et al.
BLOOD (2018)
Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing
Ke-Jia Wu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
Marc L. Hyer et al.
NATURE MEDICINE (2018)
Targeting the DCN1-UBC12 Protein-protein Interaction for Selective Modulation of Cullin Substrates
Yuan Fang et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2018)
Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials
Bo Yuan et al.
CANCER LETTERS (2017)
Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure-Based Virtual Screening
Peng Lu et al.
ACS CHEMICAL BIOLOGY (2016)
Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study
Ronan T. Swords et al.
BRITISH JOURNAL OF HAEMATOLOGY (2015)
Process Development and GMP Production of a Potent NAE Inhibitor Pevonedistat
Ian Armitage et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2015)
Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer
Lihui Li et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)
Ubiquitination in disease pathogenesis and treatment
Doris Popovic et al.
NATURE MEDICINE (2014)
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis
Ping Xie et al.
NATURE COMMUNICATIONS (2014)
Targeting the Neddylation Pathway to Suppress the Growth of Prostate Cancer Cells: Therapeutic Implication for the Men's Cancer
Xiaofang Wang et al.
BIOMED RESEARCH INTERNATIONAL (2014)
Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control
Annamaria Mocciaro et al.
JOURNAL OF CELL SCIENCE (2012)
Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives
D. Chen et al.
CURRENT CANCER DRUG TARGETS (2011)
Stereoselective Synthesis of MLN4924, an Inhibitor of NEDD8-Activating Enzyme
Hyuk Woo Lee et al.
JOURNAL OF ORGANIC CHEMISTRY (2011)
Identification of NAE Inhibitors Exhibiting Potent Activity in Leukemia Cells: Exploring the Structural Determinants of NAE Specificity
Julie L. Lukkarila et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB-dependent lymphoma
Michael A. Milhollen et al.
BLOOD (2010)
Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia
Ronan T. Swords et al.
BLOOD (2010)
Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ
James E. Brownell et al.
MOLECULAR CELL (2010)
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Teresa A. Soucy et al.
NATURE (2009)
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression
Jian-Hua Mao et al.
SCIENCE (2008)
Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma
Kongthawat Chairatvit et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2007)
Ubiquitin ligases: cell-cycle control and cancer
KI Nakayama et al.
NATURE REVIEWS CANCER (2006)
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis
H Nishitani et al.
EMBO JOURNAL (2006)
A small molecule-kinase interaction map for clinical kinase inhibitors
MA Fabian et al.
NATURE BIOTECHNOLOGY (2005)
The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle
A Hershko
CELL DEATH AND DIFFERENTIATION (2005)
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
M Yada et al.
EMBO JOURNAL (2004)
A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination
VN Podust et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)