相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor
Kunal Kumar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis
Helmi Tazarki et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
Vaclav Nemec et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics
Dnyandev B. Jarhad et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors
Anna Czarna et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature
Thu Lan Nguyen et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2017)
Structure-Based Design and Synthesis of Harmine Derivatives with Different Selectivity Profiles in Kinase versus Monoamine Oxidase Inhibition
Balazs Balint et al.
CHEMMEDCHEM (2017)
Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules
Ulli Rothweiler et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
10-lodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A
Hannes Falke et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
A novel DYRK1A (Dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro
Severine Coutadeur et al.
JOURNAL OF NEUROCHEMISTRY (2015)
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
Peng Wang et al.
NATURE MEDICINE (2015)
Inhibition of DYRK1A and GSK3B induces human β-cell proliferation
Weijun Shen et al.
NATURE COMMUNICATIONS (2015)
DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis
P. Fernandez-Martinez et al.
MOLECULAR & CELLULAR ONCOLOGY (2015)
First Selective Dual Inhibitors of Tau Phosphorylation and Beta-Amyloid Aggregation, Two Major Pathogenic Mechanisms in Alzheimer's Disease
Marica Mariano et al.
ACS CHEMICAL NEUROSCIENCE (2014)
Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance
Latif Rachdi et al.
CELL CYCLE (2014)
Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity
Alison J. Hole et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer's?
Breland Smith et al.
ACS CHEMICAL NEUROSCIENCE (2012)
7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes
Kilian Huber et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
DYRK1A Kinase Inhibitors with Emphasis on Cancer
A. Ionescu et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2012)
Activation, regulation, and inhibition of DYRK1A
Walter Becker et al.
FEBS JOURNAL (2011)
The role of DYRK1A in neurodegenerative diseases
Jerzy Wegiel et al.
FEBS JOURNAL (2011)
Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A
Yasushi Ogawa et al.
NATURE COMMUNICATIONS (2010)
Down syndrome-recent progress and future prospects
Frances K. Wiseman et al.
HUMAN MOLECULAR GENETICS (2009)
Protonate3D: Assignment of ionization states and hydrogen coordinates to macromolecular structures
Paul Labute
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2009)
DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding
Monica Alvarez et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
High-affinity binding of, β-carbolines to imidazoline I2B receptors and MAO-A in rat tissues:: Norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain
A Miralles et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2005)
Toward an artificial oxidative DNA photolyase
M Pauvert et al.
JOURNAL OF ORGANIC CHEMISTRY (2004)
分享论文
