期刊
JOURNAL OF MEDICAL VIROLOGY
卷 93, 期 8, 页码 5103-5109出版社
WILEY
DOI: 10.1002/jmv.27013
关键词
cervical cancer; genotypes; high‐ risk HPV; infection; prevalence
类别
This study investigated HPV infection in 46,365 patients in Beijing and found variations in HR-HPV genotype distribution among cervical cancer patients, with single HR-HPV infection being dominant. There were significant differences in HR-HPV infection rates among different age and disease groups.
Cervical cancer (CC) is highly associated with high-risk human papillomavirus (HPV) infection and genotype distribution of high-risk HPV (HR-HPV) infection varies greatly in different regions. Clinical specimens were collected from 46 365 patients at Beijing Friendship Hospital, Capital Medical University from January 2017 to December 2020. HPV DNA genotype testing was performed using real-time PCR. The infection rates based on disease group were compared using the chi(2) test. The linear-by-linear association test and gamma value were used to assess the changes in HPV prevalence over calendar year and age group. A total of 10 514 women were infected with HR-HPV, with an overall positive rate of 22.7%. The most prevalent HR-HPV types were HPV52, 58, 16, 51, and 66, and HPV59 had a higher prevalence except for HPV16, 58, and 52 in the CC group. Single infection of HR-HPV was dominant among different disease groups. The infection rate of HR-HPV decreased first and then increased from below 20 years old to over 60 years old. There were significant differences in the HR-HPV infection rates among the age and disease groups. Our findings demonstrate that the genotype distribution of HR-HPV varied with age and diseases. The HR-HPV genotypes prevalence was found to be directly useful for local governments to promote HPV targeted vaccination in the study region.
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