期刊
JOURNAL OF MEDICAL VIROLOGY
卷 93, 期 9, 页码 5285-5294出版社
WILEY
DOI: 10.1002/jmv.27075
关键词
angiotensin-converting enzyme 2 (ACE2); co-morbidity-COVID-19; cytokine Storm; SARS-CoV-2; vitamin D deficiency
类别
资金
- Howard University College of Medicine Bridge Funds and Pilot Study Awards Program [BFPSAP 2020-2021]
- NIH/NIGMS [2 SO6 GM08016-39]
This article focuses on the impact of age, gender, and ethnicity on the interaction between vitamin D and ACE2, as well as susceptibility to COVID-19. It suggests that vitamin D deficiency may exacerbate the severity of COVID-19 by influencing ACE2.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, disproportionally targets older people, particularly men, ethnic minorities, and individuals with underlying diseases such as compromised immune system, cardiovascular disease, and diabetes. The discrepancy in COVID-19 incidence and severity is multifaceted and likely involves biological, social, as well as nutritional status. Vitamin D deficiency, notably common in Black and Brown people and elderly, is associated with an increased susceptibility to many of the diseases comorbid with COVID-19. Vitamin D deficiency can cause over-activation of the pulmonary renin-angiotensin system (RAS) leading to the respiratory syndrome. RAS is regulated in part at least by angiotensin-converting enzyme 2 (ACE2), which also acts as a primary receptor for SARS-CoV-2 entry into the cells. Hence, vitamin D deficiency can exacerbate COVID-19, via its effects on ACE2. In this review we focus on influence of age, gender, and ethnicity on vitamin D-ACE2 interaction and susceptibility to COVID-19.
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