期刊
JOURNAL OF MATHEMATICAL BIOLOGY
卷 82, 期 6, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00285-021-01599-x
关键词
Glioblastoma; Pseudopalisade patterns; Hypoxia-induced tumor behavior; Kinetic transport equations; Upscaling; Reaction-diffusion-taxis equations; Global existence; Uniqueness; Long time behavior; Multiscale modeling; Directed; undirected tissue
资金
- DAAD
- BMBF [GlioMaTh 05M2016]
This study proposes a multiscale modeling approach to investigate the diffusion and growth of gliomas. Simulation results show that patterns similar to pseudopalisades can be formed in certain parameter ranges, correlating with tumor grade. The brain tissue may be undirected, which is crucial for glioma migration.
Gliomas are primary brain tumors with a high invasive potential and infiltrative spread. Among them, glioblastoma multiforme (GBM) exhibits microvascular hyperplasia and pronounced necrosis triggered by hypoxia. Histological samples showing garland-like hypercellular structures (so-called pseudopalisades) centered around the occlusion site of a capillary are typical for GBM and hint on poor prognosis of patient survival. We propose a multiscale modeling approach in the kinetic theory of active particles framework and deduce by an upscaling process a reaction-diffusion model with repellent pH-taxis. We prove existence of a unique global bounded classical solution for a version of the obtained macroscopic system and investigate the asymptotic behavior of the solution. Moreover, we study two different types of scaling and compare the behavior of the obtained macroscopic PDEs by way of simulations. These show that patterns (not necessarily of Turing type), including pseudopalisades, can be formed for some parameter ranges, in accordance with the tumor grade. This is true when the PDEs are obtained via parabolic scaling (undirected tissue), while no such patterns are observed for the PDEs arising by a hyperbolic limit (directed tissue). This suggests that brain tissue might be undirected - at least as far as glioma migration is concerned. We also investigate two different ways of including cell level descriptions of response to hypoxia and the way they are related .
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