期刊
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
卷 35, 期 25, 页码 6115-6123出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14767058.2021.1907332
关键词
Preterm birth; leukemia; lymphoma; gestational age; premature
资金
- National Cancer Institute [P30 CA086862-18S6]
In both California and Iowa, women with a history of leukemia or lymphoma are at increased risk for preterm birth. This highlights the importance of counseling and monitoring for women with a history of leukemia or lymphoma before and during pregnancy.
Objective Leukemia and lymphoma are top cancers affecting children, adolescents and young adults with high five-year survival rates. Late effects of these cancers are a concern in reproductive-age patients, including pregnancy outcomes such as preterm birth. Our study aimed to evaluate whether diagnosis of leukemia or lymphoma prior to pregnancy was associated with preterm birth (<37 weeks gestation). Methods We conducted a cross-sectional study using a population-based dataset from California with linked birth certificates to hospital discharge records and an Iowa-based sample that linked birth certificates to Surveillance, Epidemiology, and End Results (SEER) cancer registry data. Preterm birth was defined using birth certificates. We ascertained history of leukemia and lymphoma using discharge diagnosis data in California and SEER registry in Iowa. Results Prevalence of preterm birth in California and Iowa was 14.6% and 12.0%, respectively, in women with a history of leukemia/lymphoma compared to 7.8% and 8.2%, respectively, in women without a cancer history. After adjusting for maternal age, race, education, smoking, and plurality, Women with history of leukemia/lymphoma were at an increased risk of having a preterm birth in California (odds ratio (OR) 1.89; 95% confidence interval (CI) 1.56-2.28) and Iowa (OR 1.61; 95% CI 1.10-2.37) compared to those with no cancer history. Conclusion In both California and Iowa, women with a history of leukemia or lymphoma were at increased risk for preterm birth. This suggests the importance of counseling with a history of leukemia/lymphoma prior to pregnancy and increased monitoring of women during pregnancy.
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