Investigation of cytotoxicity of superparamagnetic KFeO2 nanoparticles on MCF-7 cell lines for biomedical applications

Superparamagnetic nanoparticles hold great potential for biomedical applications due to their exceptional properties. Biocompatible KFeO2 superparamagnetic nanoparticles have been synthesized by the bottom-up approach. X-ray diffraction (XRD), transmission electron microscope (TEM), Fourier transform infrared (FTIR) spectroscopy, vibrating sample magnetometer (VSM), and cytotoxicity test by MTT assay have been performed to understand the structure, morphology, magnetic, and toxicity properties, respectively. XRD patterns have been indexed and refined by the Rietveld refinement and used to calculate the various structural parameters. XRD revealed the orthorhombic crystal structure of KFeO2. TEM suggested that the average particle size of KFeO2 nanoparticles is 13 nm with spherical morphology. The magnetic study discloses the superparamagnetic behavior of KFeO2 nanoparticles. The toxicity of the KFeO2 nanoparticles has been analyzed by MTT revealed their high cell viability. The various factors responsible for the toxicity of nanoparticles along with the incorporation and degradation mechanism of the nanoparticles have been presented.

Automated summary

Biocompatible KFeO2 superparamagnetic nanoparticles were synthesized and characterized for their structure, morphology, magnetic properties, and toxicity. The nanoparticles exhibited a high cell viability and superparamagnetic behavior, with an average particle size of 13 nm and an orthorhombic crystal structure. The study also presented factors affecting nanoparticle toxicity and their incorporation and degradation mechanisms.