Biomaterials based cardiac patches for the treatment of myocardial infarction

Myocardial infarction (MI) is one of the common cardiovascular diseases that occurs with a blockage in one or more of the coronary arteries to lead to the damage of the myocardium, resulting in a life threatening condition. To repair the damaged myocardium in MI, researchers are looking forwards to new ways to postpone the progression of myocardial injury. Cardiac patches, the scaffolds layered on the heart surface, can provide mechanical support for the infarction site and improve cardiac function by delivering various bioactive factors or cells, showing considerable curative effect in the treatment of MI. Biomaterials with certain biocompatibility and mechanical properties have received widespread attention for the application in cardiac patches. In this review, we focus on the recent progress on these biomaterialsbased cardiac patches, which could be categorized into two types according to the sources of materials including (i ) natural materials and ( ii ) synthetic materials. The major advantages and current challenges of each type are discussed and a brief perspective on the future research directions is presented. (c) 2021 Published by Elsevier Ltd on behalf of Chinese Society for Metals.

Automated summary

Myocardial infarction, a life-threatening cardiovascular disease, can be treated effectively by using cardiac patches to support the infarction site and improve cardiac function through the delivery of bioactive factors or cells. Biomaterial-based cardiac patches, categorized into natural and synthetic materials, have advantages and challenges that need to be addressed for future research directions.