期刊
EUROPEAN JOURNAL OF EPIDEMIOLOGY
卷 31, 期 3, 页码 255-266出版社
SPRINGER
DOI: 10.1007/s10654-016-0119-9
关键词
Amyotrophic Lateral Sclerosis; Physical activity; Cohort study; EPIC study; Vigorous physical activity; BMI
资金
- European Community [QLK4CT199900927]
- Compagnia di San Paolo
- Europe Against cancer Program of the European Commission (SANCO)
- ISCIII, Red de Centros RCESP [C03/09]
- Spanish Ministry of Health [ISCIII RETICC RD06/0020]
- Deutsche Krebshilfe
- Deutsches Krebsforschungszentrum
- German Federal Ministry of Education and Research
- Danish Cancer Society
- Health Research Fund (FIS) of the Spanish Ministry of Health
- Spanish Regional Government of Andalucia
- Spanish Regional Government of Asturias
- Spanish Regional Government of Basque Country
- Spanish Regional Government of Murcia
- Spanish Regional Government of Navarra
- Spanish Ministry of Health Cancer Research UK [ISCIII RETICC RD06/0020]
- Medical Research Council, United Kingdom
- Stroke Association, United Kingdom
- British Heart Foundation
- Department of Health, United Kingdom
- Food Standards Agency, United Kingdom
- Wellcome Trust
- United Kingdom Greek Ministry of Health
- Greek Ministry of Education
- Italian Association for Research on Cancer (AIRC)
- Italian National Research Council
- Dutch Ministry of Public Health, Welfare and Sports (VWS)
- Netherlands Cancer Registry (NKR)
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands (The Netherlands)
- Swedish Cancer
- Swedish Scientific Council
- Regional Government of Skane and Vasterbotten, Sweden
- Norwegian Cancer Society
- Research Council of Norway
- French League against cancer
- Inserm
- Mutuelle Generale l'Education National
- IGR
- MRC [MC_UU_12015/1] Funding Source: UKRI
- Cancer Research UK [16491] Funding Source: researchfish
- Medical Research Council [MC_UU_12015/1, MC_PC_13048, MC_U106179471] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10135, NF-SI-0611-10084] Funding Source: researchfish
Previous case-control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33 % less likely to die from ALS compared to those inactive: HR = 0.67 (95 % CI 0.42-1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased-not increased like in case-control studies-risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity.
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