期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 54, 期 4, 页码 1177-1186出版社
WILEY
DOI: 10.1002/jmri.27612
关键词
pancreas; IPMN; diagnostic performance; abbreviated MRI; breath‐ hold 3D‐ MRCP; malignant risk assessment
The abbreviated MRI-BH showed good diagnostic performance for detecting malignant IPMNs with a sensitivity of 97.1% and specificity ranging from 85.0% to 86.0%. In detecting mural nodules, the sensitivity was between 86.4% to 95.5%, and specificity ranged from 88.3% to 92.0%. There were no significant differences in the AUC between abbreviated MRI-BH and full-sequence MRI for detecting malignant IPMN.
Background For surveillance of pancreatic intraductal papillary mucinous neoplasms (IPMNs), magnetic resonance imaging (MRI)/magnetic resonance cholangiopancreatography (MRCP) is preferred over computed tomography, but the long acquisition time limits its use. Purpose To investigate the diagnostic performance of abbreviated MRI with breath-hold (BH) three-dimensional MRCP (abbreviated MRI-BH) for malignant risk assessment of pancreatic IPMN. Study Type Retrospective. Population Two hundred and thirty-five patients with IPMNs (M:F = 115:120; mean age +/- SD, 66 +/- 9 years; typical imaging features with >= 2-year stability [N = 172] and histopathologically confirmed [N = 63]). Field Strength/Sequence 3.0 T/ abbreviated MRI-BH (single-shot fast spin-echo, T1W fat-suppressed gradient-echo sequence, and BH-3D-MRCP). Assessment Abbreviated MRI-BH was reviewed by three reviewers, and its diagnostic performance was assessed using the predetermined scoring system. The diagnostic performance for the mural nodule detection was assessed. Additionally, diagnostic performance of abbreviated MRI was compared with that of full-sequence MRI. Statistical Tests Area under the receiver operating characteristic curve (AUC) with z-test, and linear-weighted kappa values. Results Thirty-five patients had malignant IPMN. At a cut-off score >= 3, AUCs of abbreviated MRI-BH for detecting malignant IPMN were 0.959 for reviewer 1, 0.962 for reviewer 2, and 0.956 for reviewer 3. The sensitivity of reviewers 1, 2, and 3 was 97.1% for all, and the specificity was 85.5%, 86.0%, and 85.0%, respectively. Regarding mural nodule detection (N = 22), abbreviated MRI-BH demonstrated a sensitivity of 95.5% and a specificity of 88.3% for reviewer 1, a sensitivity of 86.4% and a specificity of 92.0% for reviewer 2, and a sensitivity of 86.4% and a specificity of 89.2% for reviewer 3. There were no significant differences between AUC of abbreviated MRI-BH and that of full-sequence MRI in the three reviewers (P > 0.05). Data Conclusion Abbreviated MRI-BH showed good diagnostic performance for detecting malignant IPMNs by using a predetermined scoring system. Level of Evidence 3 Technical Efficacy Stage 2
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