期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 54, 期 3, 页码 912-922出版社
WILEY
DOI: 10.1002/jmri.27605
关键词
cerebral blood flow; cerebrovascular reactivity; moyamoya; atherosclerosis; intracranial stenosis; stroke
资金
- NIH/NINDS [5R01NS078828, 1R01NS097763]
- American Heart Association [14GRNT20150004, 19CDA34790002]
The study found that an elevated CVRDELAY in patients with atherosclerosis may indicate brain parenchyma at increased risk for new infarcts. 15% of participants were found to have new infarcts during follow-up.
Background Patients with symptomatic atherosclerotic and non-atherosclerotic (i.e., moyamoya) intracranial steno-occlusive disease experience high 2-year infarct rates. Purpose To investigate whether cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) measures may provide biomarkers of 1-to-2-year infarct risk. Study Type Prospective, longitudinal study. Subjects Adult participants (age = 18-85 years) with symptomatic intracranial atherosclerotic disease (N = 26) or non-atherosclerotic (i.e., moyamoya; N = 43) and stenosis >= 50% of a major intracranial artery were initially scanned within 45 days of stroke. Follow-up imaging (target = 1.5 years) was acquired for new infarct assessment. Field Strength/Sequence 3.0 Tesla with normocapnic arterial spin labeling (ASL) and blood oxygenation level-dependent (BOLD) imaging acquired during an interleaved hypercapnic (3 minutes) and normocapnic (3 minutes) respiratory stimulus. Assessment CBF, maximum CVR, and time-to-maximum CVR (i.e., CVRDELAY) were calculated. Laterality indices (difference between infarcted and contralesional hemispheres divided by sum of absolute values) of metrics at enrollment were contrasted between participants with vs. without new infarcts on follow-up. Statistical Tests Laterality indices were compared using non-parametric Wilcoxon tests (significance: two-sided P < 0.05) and effect sizes as Cohen's d. Continuous variables are presented as mean +/- SD. Results New infarcts were observed on follow-up in 15.0% of participants. The laterality index of the CVRDELAY was elevated (P = 0.01) in participants with atherosclerosis with new infarcts (index = 0.13) compared to participants without new infarcts (index = 0.05). Data Conclusion Elevated CVRDELAY may indicate brain parenchyma at increased risk for new infarcts in patients with symptomatic intracranial atherosclerotic disease treated with standard-of-care medical management. Level of Evidence 2 Technical Efficacy Stage 3
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据