期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 141, 期 10, 页码 2449-2458出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2021.01.038
关键词
-
类别
资金
- LEO Foundation
- Danish Cancer Society
- Fight Cancer Program
- Novo Nordisk Research Foundation
- Novo Nordisk Foundation Tandem Program [NNF21OC0066950]
- Lundbeck Foundation
- Danish Council for Independent Research (Danmarks Frie Forskningsfond) [DFF4092-00122]
- NIH [HL-125816]
- LEO Foundation [LF-OC-20-000351]
- NYU Cancer Center Pilot Grant [P30CA016087]
Staphylococcal enterotoxins induce the expression of oncogenic miR-155 in malignant T cells, promoting disease activity in cutaneous T-cell lymphoma. Antibiotics inhibit this process, but the specific mechanism is not fully understood.
Staphylococcal enterotoxins are believed to fuel disease activity in cutaneous T-cell lymphoma. Recent data support this by showing that antibiotics inhibit malignant T cells in skin lesions in mycosis fungoides and Se acute accent zary syndrome, the most common forms of cutaneous T-cell lymphoma. Yet, it remains incompletely characterized how staphylococcal enterotoxins fuel disease activity. In this study, we show that staphylococcal enterotoxins induce the expression of the oncogenic microRNA miR-155 in primary malignant T cells. Thus, staphylococcal enterotoxins and Staphyloccocus aureus isolates from lesional skin of patients induce miR-155 expression at least partly through the IL-2Rg-Jak-signal transducer and activator of transcription 5 pathway, and the effect is augmented by the presence of nonmalignant T cells. Importantly, mycosis fungoides lesions harbor S. aureus, express Y-phosphorylated signal transducer and activator of transcription 5, and display enhanced miR-155 expression, when compared with nonlesional and healthy skin. Preliminary data show that aggressive antibiotic therapy is associated with decreased Y-phosphorylated signal transducer and activator of transcription 5 and miR-155 expression in lesional skin in two patients with Se acute accent zary syndrome. In conclusion, we show that S. aureus and its enterotoxins induce enhanced expression of oncogenic miR-155, providing mechanistic insight into the role of S. aureus in cutaneous T-cell lymphoma. Our findings support that environmental stimuli such as bacteria can fuel disease progression in cutaneous T-cell lymphoma. Journal of Investigative Dermatology (2021) 141, 2449e2458; doi:10.1016/j.jid.2021.01.038
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据