New Frontiers in Psoriatic Disease Research, Part II: Comorbidities and Targeted Therapies

Although psoriasis and psoriatic arthritis (PsA) have been classically considered to be diseases of the skin and joints, respectively, emerging evidence suggests that a combination of innate and environmental factors creates widespread immune dysfunction, affecting multiple organ systems. A greater understanding of the pathogenesis of psoriasis and the systemic effects of psoriatic inflammation has allowed for the development of new, more effective treatments. The second portion of this two-part review series examines the comorbidities associated with psoriasis and PsA as well as the most recent advances in targeted systemic therapies for these conditions.

Automated summary

Psoriasis and psoriatic arthritis are not just diseases of the skin and joints, but rather immune dysfunction disorders caused by a combination of innate and environmental factors. Understanding the pathogenesis and systemic effects of psoriatic inflammation has led to the development of new and more effective treatments.