期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 49, 期 4, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/03000605211001643
关键词
Vitamin K-2; atypical femoral fracture; bisphosphonate; secondary osteoporosis; radiographic examination; case report
资金
- National Key Research and Development Program of China [2017YFB1304200]
An atypical femoral fracture (AFF) is a rare complication associated with excessive inhibition of osteoclast expression during osteoporosis treatment, and vitamin K-2 (VK2) may have potential beneficial effects on the healing of AFFs. This case report suggests that VK2 could be a potential direction for pharmacological treatment of AFFs in future research.
An atypical femoral fracture (AFF) is a rare complication associated with excessive inhibition of osteoclast expression during treatment of osteoporosis. We herein describe a patient who had been treated with alendronate for more than 10 years and subsequently developed an AFF that healed after treatment with vitamin K-2 (VK2). We also discuss the potential beneficial effects of VK2 on the healing of AFFs. A 48-year-old Asian man with secondary osteoporosis was treated with alendronate for more than 10 years. The patient underwent surgical treatment for a complete AFF of the right femur. Six months postoperatively, he complained of pain in his left thigh. X-ray examination revealed an incomplete AFF of the left femoral shaft. He was then treated with VK2. After 4 months of VK2 treatment, the patient reported that the pain in his left thigh had decreased, and follow-up X-ray examination demonstrated healing of the left AFF line. This case report indicates that VK2 may be a potential direction for pharmacological treatment of AFFs in future research.
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